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Updated: May 15, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

Interplay between genomic alterations and androgen receptor signaling during prostate cancer development and

Michael D Nyquist1, Scott M Dehm

  • 1Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA.

Hormones & Cancer
|January 12, 2013
PubMed

Insights

Advanced prostate cancer (PCa) progresses to castration-resistant PCa (CRPC) despite androgen deprivation therapy (ADT). Genomic alterations, particularly in the androgen receptor (AR) gene, drive this resistance and CRPC progression.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Advanced prostate cancer (PCa) often becomes resistant to androgen deprivation therapy (ADT), progressing to castration-resistant PCa (CRPC).
  • Understanding the genomic underpinnings of PCa development and ADT resistance is crucial for therapeutic advancement.

Purpose of the Study:

  • To review key genomic alterations involved in prostate cancer (PCa) development and progression.
  • To elucidate the role of these genomic changes in the development of castration-resistant prostate cancer (CRPC) and resistance to androgen deprivation therapy (ADT).

Main Methods:

  • Integrative genomic analyses of PCa.
  • Review of studies focusing on androgen receptor (AR) signaling axis alterations.
  • Examination of AR gene alterations including amplification, mutations, and rearrangements.

Main Results:

  • Alterations in the androgen receptor (AR) signaling axis are central to CRPC progression.
  • Frequent AR gene alterations in CRPC include amplification, point mutations, and rearrangements.
  • AR gene rearrangements can lead to constitutively active AR splice variants resistant to ADT.

Conclusions:

  • Genomic alterations significantly impact PCa development and progression.
  • Understanding AR signaling axis modifications is key to addressing ADT resistance in CRPC.
  • Targeting AR pathway alterations may offer new therapeutic strategies for advanced prostate cancer.

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