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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Everolimus causing severe hypertriglyceridemia and acute pancreatitis.
Somasundaram Subramaniam1, Jason A Zell, Pamela L Kunz
1Stanford Cancer Institute, Stanford, California, USA.
Journal of the National Comprehensive Cancer Network : JNCCN
|January 12, 2013
Summary
Everolimus, an mTOR inhibitor, can cause severe hypertriglyceridemia and pancreatitis in patients with metastatic pancreatic neuroendocrine tumors (pNETs). Monitoring and management strategies allow continued treatment.
Area of Science:
- Oncology
- Pharmacology
- Endocrinology
Background:
- Everolimus is an mTOR inhibitor used for metastatic pancreatic neuroendocrine tumors (pNETs), renal cell carcinoma, and posttransplant immunosuppression.
- Hypertriglyceridemia and acute pancreatitis are potential serious side effects of everolimus therapy.
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