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Live attenuated and inactivated influenza vaccine in school-age children

W C Gruber1, L H Taber, W P Glezen

  • 1Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Tex.

American Journal of Diseases of Children (1960)
|May 1, 1990
PubMed

Insights

A single dose of trivalent inactivated influenza vaccine effectively protected school-age children against influenza B infection, demonstrating significant efficacy during an epidemic. This study highlights the vaccine

Area of Science:

  • Immunology
  • Vaccinology
  • Public Health

Background:

  • Influenza poses a significant public health threat, particularly to school-aged children.
  • Evaluating the immunogenicity and efficacy of different influenza vaccine formulations is crucial for disease prevention.

Purpose of the Study:

  • To compare the protective efficacy of a cold-recombinant bivalent A vaccine against a commercial trivalent inactivated influenza vaccine in school-age children.
  • To assess the serologic response and protection against influenza B infection provided by a single dose of trivalent inactivated vaccine.

Main Methods:

  • A double-blind, placebo-controlled study involving 189 families and 360 school-age children (3-18 years).
  • Vaccination with cold-recombinant bivalent A vaccine, trivalent inactivated vaccine, or placebo.
  • Measurement of hemagglutination-inhibition antibody titers and assessment of protection during the 1985-1986 influenza B epidemic.

Main Results:

  • Trivalent inactivated vaccine recipients showed higher antibody responses to A/H1N1 and A/H3N2 compared to the recombinant vaccine.
  • 67% of trivalent inactivated vaccine recipients achieved a serologic response to H1N1, H3N2, and influenza B after one dose.
  • The trivalent inactivated vaccine demonstrated 62% heterotypic protection against influenza B and 64% protection against infection.

Conclusions:

  • A single dose of commercial trivalent inactivated influenza vaccine is effective in protecting school-age children against influenza B.
  • The trivalent inactivated vaccine provides significant protection against influenza B infection and associated febrile illness.
  • These findings support the use of trivalent inactivated influenza vaccine for influenza B prevention in pediatric populations.

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