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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Historical changes in epidemiology of diffuse panbronchiolitis.

C Kono¹, T Yamaguchi, Y Yamada

¹Department of Respiratory Medicine, Japan Railway Tokyo General Hospital, Japan. Japan.

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG

|January 15, 2013

Summary

Diffuse panbronchiolitis (DPB) incidence and prevalence appear to be declining in Japan. This study observed a significant decrease in DPB cases over a 27-year period in a large company.

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Area of Science:

Pulmonology
Epidemiology
Respiratory Medicine

Background:

Japanese pulmonologists noted a decline in new diffuse panbronchiolitis (DPB) cases before the 1980s.
No prior epidemiological data supported this clinical observation of reduced DPB incidence.

Purpose of the Study:

To investigate the epidemiological trends of diffuse panbronchiolitis (DPB).
To provide data supporting the observed rarity of new DPB cases in Japan.

Main Methods:

Utilized computerized health records from JR East Company employees (1976-2003).
Identified DPB patients and conducted follow-up assessments across three distinct periods: 1976-1980, 1989-1993, and 1999-2003.

Main Results:

11 DPB cases (4 incidence, 7 prevalence) were found in 1976-1980 (355,572 workers).
3 DPB cases (1 incidence, 2 prevalence) were identified in 1989-1993 (180,359 workers).
No DPB cases were detected in 1999-2003 (144,485 workers).

Conclusions:

The epidemiological data suggest a significant decrease in both incidence and prevalence of DPB.
This trend supports the clinical observation of DPB becoming a rare event in Japan.