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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Earlobe sarcoidosis.

A D M Vorselaars¹, R G M Keijsers, J C Grutters

¹Centre of Interstitial Lung Diseases, Department of pulmnonology, St Antonius Hospital, Nieuwegein, The Netherlands. a.vorselaars@antoniusziekenhuis.nl

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG

|January 15, 2013

Summary

Infliximab, a TNF-alpha blocker, shows promise for refractory sarcoidosis. Imaging with 18F-FDG-PET can track treatment response in patients with sarcoidosis, including earlobe involvement.

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Area of Science:

Immunology
Nuclear Medicine
Dermatology

Background:

Refractory sarcoidosis presents a therapeutic challenge.
Infliximab, a tumor necrosis factor-alpha (TNF-α) inhibitor, is emerging as a treatment option.
18F-FDG-PET imaging shows potential for monitoring treatment response in pulmonary sarcoidosis.

Observation:

A case report details a patient with severe earlobe sarcoidosis.
The patient was treated with infliximab.
18F-FDG-PET was utilized to visualize the extent of the disease.

Findings:

18F-FDG-PET successfully visualized extrapulmonary sarcoidosis, even in small lesions.
A reduction in 18F-FDG uptake on PET scans correlated with clinical improvement.
This suggests 18F-FDG-PET is a viable tool for assessing treatment efficacy.

Implications:

This case highlights the utility of 18F-FDG-PET in monitoring infliximab therapy for sarcoidosis.
The findings support the use of imaging to guide treatment decisions in refractory sarcoidosis.
Early detection and monitoring of extrapulmonary sarcoidosis may be improved with this approach.