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A Minimally Invasive Method for Generating a Syngeneic Orthotopic Mouse Model of Lung Cancer
Published on: August 19, 2025
Challenges of lung cancer management in a developing country
Ndubueze Ezemba1, Eyo E Ekpe, John C Eze
1Division of Cardiothoracic Surgery, Department of Surgery, University of Nigeria Teaching Hospital, Enugu. ndubueze.ezemba@unn.edu.ng
Background:
The investigation of pulmonary neoplasm in Nigeria is hampered by lack of investigative tools and religio-cultural beliefs that detest autopsy. However, recent publications seem to suggest an increasing incidence of this lesion in Nigeria.
Materials And Methods:
A 30-month prospective study of all cases of lung cancer seen at a tertiary health institution in Nigeria was done to document the incidence and challenges of management in the region.
Results:
Fifty one new cases of primary carcinoma of the lung were identified during the study period. The age ranged from 30-81 years, mean 56.6 +/- 21.6 years and male:female ratio of 2.4:1. The age-standardized incidence rate was 7.9 per 100.000 with a peak in the 60-69 year age group. In 42% of the males there was cigarette smoking history. Adenocarcinoma of the lung was the predominant histologic subtype, and treatment was largely palliative.
Conclusion:
The incidence of lung cancer in South East Nigeria is on the increase even in the absence of state-of-the-art diagnostic modalities. The high prevalence of cigarette smoking amongst the males is a call for the intensification of the preventive measures against tobacco use.
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