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Evaluation of lipid parameters and bioindices in patients with different stages of chronic renal failure

Velibor Cabarkapa1, Mirjana Djerić, Zoran Stosić

  • 1Department of Patophysiology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia. veliborcabarkapa@gmail.com

Vojnosanitetski Pregled
|January 15, 2013
PubMed

Insights

The atherogenic index of plasma (AIP) and TG/HDL-C ratio effectively evaluate lipid disturbances in chronic renal failure (CRF) patients. These indices, along with others, highlight significant lipid alterations in hemodialysis patients compared to controls.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Clinical Biochemistry

Background:

  • Cardiovascular disease is a major concern in chronic renal failure (CRF).
  • Lipid metabolism is often dysregulated in CRF patients.
  • Understanding these lipid changes is crucial for patient management.

Purpose of the Study:

  • To assess lipid parameters and novel bioindices in CRF patients across different stages.
  • To compare lipid profiles between hemodialysis (HD), non-HD CRF, and control groups.
  • To identify the most effective markers for lipid disturbances in CRF.

Main Methods:

  • Evaluated triglycerides, total cholesterol, HDL-C, apo A-I, apo B, and other markers using standard biochemical and immunoturbidimetric methods.
  • Calculated derived lipid parameters including LDL-C, non-HDL-C, and ratios like TG/HDL-C.
  • Assessed novel bioindices such as Lipid Tetrad Index (LTI), Lipid Pentad Index (LPI), and Atherogenic Index of Plasma (AIP).

Main Results:

  • Significant differences in lipid levels (TG, HDL-C, LDL-C, non-HDL-C, total C, apo A-I) were observed between HD, non-HD CRF, and control groups.
  • Atherogenic Index of Plasma (AIP) and TG/HDL-C ratio were significantly elevated in CRF patients (HD and non-HD) compared to controls, and higher in HD than non-HD.
  • AIP > 0.11 was prevalent in 71.7% of HD patients, 56% of non-HD patients, and 31.3% of controls.

Conclusions:

  • AIP and TG/HDL-C ratio are the most suitable indices for evaluating lipid disturbances in CRF.
  • Non-HDL-C is not a recommended marker for lipid assessment in CRF.
  • Further investigation into LTI and LPI is warranted for their clinical utility in CRF.
Abstract

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