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Updated: May 15, 2026

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
Published on: May 6, 2019
Dynamics of stochastic mutation to immunodominance
Yu Wu1, Xiaopeng Zhao, Mingjun Zhang
1Department of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996, United States. walton731@hotmail.com
Abstract:
Although a virus contains several epitopes that can be recognized by cytotoxic T lymphocytes (CTL), the immune responses against different epitopes are not uniform. Only a few CTLs (sometimes just one) will be immunodominant. Mutation of epitopes has been recognized as an important mechanism of immunodominance. Previous research has studied the influences of sporadic, discrete mutation events. In this work, we introduce a bounded noise term to account for the intrinsic stochastic nature of mutation. Monte Carlo simulations of the stochastic model show abounding complex phenomena, and patterns observed from the numerical simulations shed lights on long term trends of immunodomnance.
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