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Published on: August 1, 2025
Cannabis and other illicit drug use in epilepsy patients
M Hamerle1, L Ghaeni, A Kowski
1Department of Neurology, Charité-University Hospital Berlin, Berlin, Germany.
Background And Purpose:
This study aimed to assess the prevalence of illicit drug use among epilepsy patients and its effects on the disease.
Methods:
We systematically interviewed epilepsy outpatients at a tertiary epilepsy clinic. Predictors for active cannabis use were analysed with a logistic regression model.
Results:
Overall, 310 subjects were enrolled; 63 (20.3%) reported consuming cannabis after epilepsy was diagnosed, and 16 (5.2%) used other illicit drugs. Active cannabis use was predicted by sex (male) [odds ratio (OR) 5.342, 95% confidence interval (95% CI) 1.416-20.153] and age (OR 0.956, 95% CI 0.919-0.994). Cannabis consumption mostly did not affect epilepsy (84.1%). Seizure worsening was observed with frequent illicit (non-cannabis) drug use in 80% of cases.
Conclusions:
Cannabis use does not seem to affect epilepsy; however, frequent use of other drugs increases seizure risk.
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