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Updated: May 15, 2026
Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
In vivo evaluation of a novel implant coating agent: laminin-1
Kostas Bougas1, Ryo Jimbo, Stefan Vandeweghe
1Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
Purpose:
The aim of this study was to assess the effect of implant coating with laminin-1 on the early stages of osseointegration in vivo.
Materials And Methods:
Turned titanium implants were coated with the osteoprogenitor-stimulating protein, laminin-1 (TL). Their osteogenic performance was assessed with removal torque, histomorphometry, and nanoindentation in a rabbit model after 2 and 4 weeks. The performance of the test implants was compared with turned control implants (T), alkali- and heat-treated implants (AH), and AH implants coated with laminin-1.
Results:
After 2 weeks, TL demonstrated significantly higher removal torque as compared with T and equivalent to AH. Bone area was significantly higher for the test surface after 4 weeks, while no significant changes were detected on the micromechanical properties of the surrounding bone.
Conclusions:
Within the limitations of this study, our results suggest a great potential for laminin-1 as a coating agent. A turned implant surface coated with laminin-1 could enhance osseointegration comparable with a bioactive implant surface while keeping the surface smooth.
