Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cervicomedullary motor evoked responses in individuals with severe chronic hemiparesis post-stroke: a feasibility study.

Frontiers in neurology·2026

Same author

Neurorehabilitation needs a qualitative perspective: a case exemplar from stroke recovery and rehabilitation.

Frontiers in human neuroscience·2026

Same author

Optimizing the Approach to Calculating CST Lesion Load in Ischemic Stroke Patients for Understanding Motor Outcomes.

Neurorehabilitation and neural repair·2026

Same author

Neurorehabilitation in the 21st Century: New Science, New Strategies, New Expectations.

Neurorehabilitation and neural repair·2026

Same author

Targeted Remediation of the Ipsilesional Arm in Chronic Stroke: A Randomized Clinical Trial.

JAMA neurology·2026

Same author

Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational study.

The Lancet. Digital health·2026

Search research articles

Related Experiment Video

Updated: May 15, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Interdisciplinary Comprehensive Arm Rehabilitation Evaluation (ICARE): a randomized controlled trial protocol.

Carolee J Winstein¹, Steven L Wolf, Alexander W Dromerick

¹Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry University of Southern California, Los Angeles, CA, USA. winstein@usc.edu

|January 15, 2013

Summary

This study evaluated the Accelerated Skill Acquisition Program (ASAP) for upper extremity stroke recovery. ASAP showed potential for improving arm and hand function compared to usual therapy, offering new hope for stroke survivors.

More Related Videos

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients

Published on: October 11, 2024

Related Experiment Videos

Last Updated: May 15, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients

Published on: October 11, 2024

Area of Science:

Neurology
Rehabilitation Medicine
Clinical Trials

Background:

Stroke frequently results in significant upper extremity disability, impacting daily activities for many survivors.
Task-oriented training is increasingly used, but optimal protocols and dosage remain undefined.
The Interdisciplinary Comprehensive Arm Rehabilitation Evaluation (ICARE) Stroke Initiative addresses this gap by evaluating a structured rehabilitation program.

Purpose of the Study:

To determine if the Accelerated Skill Acquisition Program (ASAP) improves arm and hand recovery more than usual therapy of equivalent dose (DEUCC) one year post-stroke.
To compare ASAP against true usual and customary care (UCC).
To compare DEUCC against UCC.

Main Methods:

A three-arm, single-blind, superiority randomized controlled trial involving 360 adults with mild to moderate upper extremity impairment post-stroke.
Participants were randomized 14-106 days after stroke onset.
The primary outcome was the Wolf Motor Function Test (WMFT) time score at 1 year; the Stroke Impact Scale (SIS) hand domain was a secondary outcome.

Main Results:

The primary hypothesis posits greater improvement in log-transformed WMFT time for the ASAP group compared to the DEUCC group.
Secondary analyses will compare ASAP to UCC and DEUCC to UCC.
The study is designed with concealed allocation, blinded outcome assessment, and intention-to-treat analyses.

Conclusions:

The ICARE trial will ascertain if the ASAP intervention is superior to an equivalent dose of usual therapy for upper extremity recovery after stroke.
Further analyses will investigate if a standardized 30-hour usual therapy approach is better than current, non-dose-controlled usual care.
Findings will inform evidence-based upper extremity rehabilitation protocols for stroke survivors.