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Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...

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Articles linked to this work by shared authors, journal, and citation graph.

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Alternative Lengthening of Telomeres is dependent on RAD52 and RAD51 gene function in the budding yeast Naumovozyma castellii.

G3 (Bethesda, Md.)·2026
Same author

Subtelomeric elements provide stability to short telomeres in telomerase-negative cells of the budding yeast Naumovozyma castellii.

Current genetics·2025
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Characterization of the <i>RAD52</i> Gene in the Budding Yeast <i>Naumovozyma castellii</i>.

Genes·2023
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Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in <i>Saccharomyces cerevisiae</i>.

eLife·2022
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The telomeric 5' end nucleotide is regulated in the budding yeast Naumovozyma castellii.

Nucleic acids research·2021
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Either Rap1 or Cdc13 can protect telomeric single-stranded 3' overhangs from degradation in vitro.

Scientific reports·2019

Related Experiment Video

Updated: May 15, 2026

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers
11:21

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers

Published on: August 30, 2024

OB Fold Contributes to Telomere Maintenance.

Marita Cohn1

  • 1Department of Biology, Genetics Group, Lund University, Sölvegatan 35, SE-223 62 Lund, Sweden.

Structure (London, England : 1993)
|January 15, 2013
PubMed
Summary

The Cdc13 protein

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Cdc13 is a key protein in the trimeric CST complex, crucial for genome stability.
  • The CST complex binds to and protects yeast telomeres, essential for DNA replication and repair.

Discussion:

  • Mason and colleagues investigated the OB fold domain (OB2) of Cdc13.
  • They propose that OB2's homo-dimerization is vital for CST complex assembly.

Key Insights:

  • The OB2 domain of Cdc13 plays a critical role in telomere maintenance.
  • Homo-dimerization of OB2 is essential for the proper formation of the CST complex.

Outlook:

  • Further research into OB2's structure and function could reveal new therapeutic targets.

More Related Videos

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

Related Experiment Videos

Last Updated: May 15, 2026

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers
11:21

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers

Published on: August 30, 2024

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

  • Understanding OB2's role may advance strategies for combating telomere-related diseases.