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Leukocyte esterase activity in amniotic fluid: normal values during pregnancy.
I A Hoskins1, F Marks, S A Ordorica
1Department of Obstetrics and Gynecology, New York University, Bellevue Medical Center, New York 10016.
American Journal of Perinatology
|April 1, 1990
Summary
Leukocyte esterase (LE) activity in amniotic fluid is a reliable indicator for detecting chorioamnionitis. This diagnostic method shows negative results when cultures are also negative, aiding in pregnancy infection diagnosis.
Area of Science:
- Obstetrics and Gynecology
- Clinical Diagnostics
- Infectious Diseases
Background:
- Chorioamnionitis diagnosis is challenging for obstetricians, requiring rapid and accurate methods.
- Leukocyte esterase (LE) activity in neutrophils is a potential marker for infection.
- Previous studies validated LE activity for term pregnancies.
Purpose of the Study:
- To establish normal values of LE activity in amniotic fluid before term.
- To assess LE activity as a predictor for chorioamnionitis in preterm pregnancies.
Main Methods:
- Prospective study involving amniotic fluid collection from 24 patients (15-19 and 25-27 weeks gestation).
- Samples were analyzed for aerobic and anaerobic cultures and LE activity using dipstick.
- Patients with ruptured membranes or preterm labor were excluded.
Main Results:
- Leukocyte esterase (LE) activity was consistently negative in amniotic fluid samples with negative culture results.
- This suggests LE activity is a specific marker for infection.
Conclusions:
- Leukocyte esterase (LE) activity is a reliable diagnostic marker for chorioamnionitis.
- Establishing normal LE values in preterm amniotic fluid is crucial for its clinical application.