Related Experiment Video
Updated: May 15, 2026
03:13
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
[Acute renal insufficiency in severe prematurity].
M Cisse1, S Ilunga, I Benmoulai
1Service de pédiatrie néonatale, CHU Caremeau, place Robert-Debré, 30029 Nîmes cedex, France. mamci76@yahoo.fr
Summary
Rhabdomyolysis, a muscle breakdown condition, can affect newborns after difficult births. This case highlights persistent kidney failure in a premature infant following birth trauma and rhabdomyolysis.
Area of Science:
- Neonatal Medicine
- Pediatric Nephrology
- Muscle Physiology
Background:
- Rhabdomyolysis is a known condition in adults, stemming from trauma, ischemia, or metabolic/toxic causes.
- Renal failure is a recognized complication of rhabdomyolysis, impacting patient prognosis.
- Neonatal rhabdomyolysis can occur due to severe asphyxia or birth-related muscular injuries.
Observation:
- A case report details a very premature infant (25 weeks 3 days gestation) born via difficult cesarean delivery.
- The infant presented with extensive hematomas, elevated urine myoglobin, and hypercreatinemia at birth.
- Rhabdomyolysis was diagnosed, and associated metabolic disturbances due to impaired renal function were managed.
Findings:
- Despite interventions, the infant developed persistent renal failure.
- The renal failure became chronic over an 18-month follow-up period.
- This case underscores the potential for long-term renal complications following neonatal rhabdomyolysis.
Implications:
- Highlights the risk of chronic kidney disease in premature infants experiencing rhabdomyolysis post-birth.
- Emphasizes the need for vigilant renal monitoring in neonates with rhabdomyolysis.
- Suggests further research into the long-term renal outcomes of neonatal rhabdomyolysis.
Related Concept Videos
01:22Acute Kidney Injury I: Introduction
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
01:29Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:29Acute Kidney Injury II: Pathophysiology
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
01:22Acute Kidney Injury VI: Nursing Management
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
01:20Acute Kidney Injury V: Interprofessional Care
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...