Related Experiment Video

Updated: May 15, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Deep cerebral microbleeds are negatively associated with HDL-C in elderly first-time ischemic stroke patients

Michiya Igase1, Katsuhiko Kohara, Keiji Igase

  • 1Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. migase@m.ehime-u.ac.jp

Journal of the Neurological Sciences
|January 15, 2013
PubMed
Abstract

Insights

Low high-density lipoprotein cholesterol (HDL-C) is linked to deep cerebral microbleeds (CMBs) in elderly stroke patients. Managing HDL-C may help prevent recurrent strokes.

Area of Science:

  • Neurology
  • Radiology
  • Cardiovascular Research

Background:

  • Cerebral microbleeds (CMBs) on MRI are linked to higher stroke risk.
  • Identifying risk factors for CMBs is crucial for stroke prevention.

Purpose of the Study:

  • To evaluate risk factors for cerebral microbleeds (CMBs) in first-time ischemic stroke patients.
  • To determine the association between lipid profiles and CMBs.

Main Methods:

  • Assessed CMBs in 116 first-time ischemic stroke patients.
  • Classified CMBs as lobar or deep/infratentorial.
  • Used logistic regression to analyze lipid profiles and CMB presence.

Main Results:

  • CMBs were found in 74 patients.
  • Deep CMBs were associated with lower HDL-C levels.
  • Low HDL-C and advanced periventricular hyperintensity (PVH>2) independently predicted deep CMBs.

Conclusions:

  • Low HDL-C may be a risk factor for deep CMBs in elderly stroke patients.
  • Advanced PVH status is also associated with deep CMBs.
  • Managing HDL-C could be a target for preventing stroke recurrence.

More Related Videos

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats06:39

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Published on: October 17, 2018

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images08:39

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

Related Concept Videos

Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...