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Updated: May 15, 2026
06:13
Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation
Published on: June 20, 2018
Olfactory changes after endoscopic sinus surgery in patients with chronic rhinosinusitis
Hideki Oka1, Kenzo Tsuzuki, Hironori Takebayashi
1Department of Otolaryngology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Auris, Nasus, Larynx
|January 15, 2013
Summary
Endoscopic sinus surgery (ESS) offers transient olfactory improvement for eosinophilic chronic rhinosinusitis (ECRS) patients, while non-ECRS patients experience sustained recovery. Preoperative prosultiamine response predicts better olfactory outcomes post-surgery.
Area of Science:
- Otolaryngology
- Rhinology
- Surgical Outcomes
Background:
- Chronic rhinosinusitis (CRS) significantly impacts olfactory function.
- Distinguishing between eosinophilic CRS (ECRS) and non-ECRS is crucial for treatment planning.
- The effect of endoscopic sinus surgery (ESS) on olfaction in these distinct CRS subtypes remains controversial.
Purpose of the Study:
- To investigate and compare the olfactory outcomes following ESS in patients diagnosed with ECRS versus non-ECRS.
- To evaluate the long-term efficacy of ESS on olfactory function in different CRS phenotypes.
Main Methods:
- A cohort of 89 adult CRS patients underwent ESS.
- Patients were categorized into ECRS (Group A) and non-ECRS (Group B) based on clinical, blood, CT, and olfactory test criteria.
- Olfactory function was assessed preoperatively and at 3, 6, 12, and 24 months post-ESS using SAOQ, VAS, T&T recognition thresholds, and prosultiamine tests.
Main Results:
- Both ECRS and non-ECRS groups showed initial olfactory improvement within 6 months post-ESS.
- Non-ECRS patients (Group B) demonstrated sustained improvement in T&T recognition thresholds for 24 months.
- ECRS patients (Group A) experienced transient improvement, with olfactory function declining after 12 months.
- A significant difference in postoperative olfactory function was observed between groups at 12 months.
- Preoperative response to prosultiamine predicted better postoperative olfactory outcomes in both groups.
Conclusions:
- Olfactory dysfunction in ECRS shows only temporary improvement after ESS, often deteriorating over time.
- Patients with non-ECRS generally experience more favorable and lasting olfactory recovery post-ESS.
- Preoperative assessment of olfactory response to prosultiamine can help predict surgical outcomes.
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