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Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Loss of Tumor Suppressor Gene Functions

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Updated: May 15, 2026

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

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Published on: August 14, 2019

Decrease of PDSS2 expression, a novel tumor suppressor, in non-small cell lung cancer.

Ping Chen¹, Jun Yu, Jodi Knecht

¹Department of Genetic and Molecular Biology, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China.

Cancer Epidemiology

|January 15, 2013

Summary

This summary is machine-generated.

Prenyl diphosphate synthase subunit 2 (PDSS2) expression is decreased in non-small cell lung cancer (NSCLC) tissues compared to normal tissues. This loss of PDSS2 is linked to poorer differentiation and advanced stages, suggesting its role as a potential tumor suppressor in NSCLC.

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Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

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Published on: January 19, 2019

Area of Science:

Molecular biology
Oncology
Gene expression analysis

Background:

Prenyl diphosphate synthase subunit 2 (PDSS2) is a potential tumor suppressor.
The role of PDSS2 in non-small cell lung cancer (NSCLC) was previously unknown.

Purpose of the Study:

To investigate the association between PDSS2 gene expression and NSCLC.
To determine if PDSS2 expression levels correlate with clinical factors in NSCLC patients.

Main Methods:

Examined PDSS2 expression levels in 28 paired NSCLC and normal lung tissue samples.
Analyzed PDSS2 expression in relation to tumor differentiation, pathological stage, lymph node metastasis, sex, histological type, smoking history, and clinical factors (EGFR, Ki-67, p53).

Main Results:

PDSS2 was consistently expressed in normal lung tissues.
Overall decreased PDSS2 expression was observed in NSCLC tissues compared to normal tissues.
Reduced PDSS2 expression was more severe in poorly differentiated tumors, advanced stages, and cases with lymph node metastasis. Expression was linked to smoking history but not sex, histological type, EGFR, Ki-67, or p53.

Conclusions:

Decreased PDSS2 expression is evident in NSCLC.
Loss of PDSS2 may serve as a potential biomarker for NSCLC development.
Further research is warranted to explore PDSS2's tumor-suppressive role and anti-tumor mechanisms in NSCLC.