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Published on: August 14, 2019
Decrease of PDSS2 expression, a novel tumor suppressor, in non-small cell lung cancer
Ping Chen1, Jun Yu, Jodi Knecht
1Department of Genetic and Molecular Biology, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China.
Background:
Prenyl diphosphate synthase subunit 2 (PDSS2) gene has recently been reported as a potential tumor suppressor. The association of PDSS2 and non-small cell lung cancer (NSCLC) has not been known.
Methods:
To investigate its association with NSCLC, we examined the expression level of PDSS2 in 28 paired clinical samples of non-small cell lung cancer tissues and surrounding normal tissues.
Results:
PDSS2 was constitutionally expressed in normal lung tissues regardless of sex, race and smoking history. An overall decreased PDSS2 expression was found in the tumor tissues compared to surrounding normal tissues. Decrease in PDSS2 expression was more severe in poorly and poor-to-moderately differentiated lung cancers, while the decrease was not significant in moderately to well-differentiated tumors. Moreover, the expression of PDSS2 decreased more in higher pathological stage, and in patients with lymph node metastasis. The decrease in PDSS2 expression in tumor tissues was not related to sex or histological type of NSCLC, but was related to smoking history. No correlation has been found between PDSS2 and the clinical factors of EGRF, Ki-67 and p53.
Conclusion:
Taken together, decreased expression of PDSS2 in NSCLC was evident. This is an initial report for the expression of PDSS2 in relation to different factors in lung cancer. Loss of PDSS2 could serve as a potential biomarker in NSCLC development. The role of PDSS2 as a tumor suppressor, and the mechanism of its potential anti-tumor action in NSCLC warrant further investigation.
Insights
Prenyl diphosphate synthase subunit 2 (PDSS2) expression is decreased in non-small cell lung cancer (NSCLC) tissues compared to normal tissues. This loss of PDSS2 is linked to poorer differentiation and advanced stages, suggesting its role as a potential tumor suppressor in NSCLC.
Area of Science:
- Molecular biology
- Oncology
- Gene expression analysis
Background:
- Prenyl diphosphate synthase subunit 2 (PDSS2) is a potential tumor suppressor.
- The role of PDSS2 in non-small cell lung cancer (NSCLC) was previously unknown.
Purpose of the Study:
- To investigate the association between PDSS2 gene expression and NSCLC.
- To determine if PDSS2 expression levels correlate with clinical factors in NSCLC patients.
Main Methods:
- Examined PDSS2 expression levels in 28 paired NSCLC and normal lung tissue samples.
- Analyzed PDSS2 expression in relation to tumor differentiation, pathological stage, lymph node metastasis, sex, histological type, smoking history, and clinical factors (EGFR, Ki-67, p53).
Main Results:
- PDSS2 was consistently expressed in normal lung tissues.
- Overall decreased PDSS2 expression was observed in NSCLC tissues compared to normal tissues.
- Reduced PDSS2 expression was more severe in poorly differentiated tumors, advanced stages, and cases with lymph node metastasis. Expression was linked to smoking history but not sex, histological type, EGFR, Ki-67, or p53.
Conclusions:
- Decreased PDSS2 expression is evident in NSCLC.
- Loss of PDSS2 may serve as a potential biomarker for NSCLC development.
- Further research is warranted to explore PDSS2's tumor-suppressive role and anti-tumor mechanisms in NSCLC.
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