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Updated: May 15, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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[Medication errors in Spanish intensive care units].

P Merino1, M C Martín, A Alonso

  • 1Servicio de Medicina Intensiva, Hospital Can Misses, Ibiza, España. pazmerino@telefonica.net

Medicina Intensiva
|January 15, 2013
PubMed
Summary
This summary is machine-generated.

Medication errors are frequent in Spanish intensive care units (ICUs), with over 25% of incidents involving medications. Most errors occur during prescription and administration, and many are avoidable, though not all cause harm.

Keywords:
Adverse eventsCritical patient safetyErrores de medicaciónEventos adversosIncident reportingMedication errorsNotificación de incidentesSeguridad del paciente crítico

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Area of Science:

  • Critical care medicine
  • Patient safety
  • Pharmacovigilance

Context:

  • Intensive care units (ICUs) are high-risk environments for medical errors.
  • Medication errors represent a significant patient safety concern globally.
  • This study focuses on medication error incidence within Spanish ICUs.

Purpose:

  • To estimate the incidence and characteristics of medication errors in Spanish ICUs.
  • To identify the phases of care where medication errors are most prevalent.
  • To assess the impact and avoidability of medication errors in critically ill patients.

Summary:

  • A post hoc analysis of the SYREC trial involving 1017 patients across 79 Spanish ICUs.
  • Identified a medication error rate of 1.13 per 100 patient-days.
  • Medication errors were most common during prescription (34%) and administration (28%), with 16% causing patient harm and 82% deemed avoidable.

Impact:

  • Highlights the substantial burden of medication errors in critically ill patients.
  • Informs strategies for improving medication safety in ICUs.
  • Emphasizes the need for interventions targeting prescription and administration phases to reduce avoidable harm.