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Updated: May 15, 2026
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Microscopic diversity in oral Kaposi sarcoma
Belinda K Bunn1, Marianne de Vasconcelos Carvalho, Melanie Louw
1Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, South Africa.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
|January 15, 2013
Summary
Kaposi sarcoma, an HIV-associated cancer, often affects the mouth. This study identified seven distinct histomorphological patterns of oral Kaposi sarcoma, aiding in diagnosis.
Area of Science:
- Oral Pathology
- Oncology
- Dermatology
Background:
- Kaposi sarcoma is the most frequent neoplasm associated with Human Immunodeficiency Virus (HIV).
- Oral mucosal involvement is a common presentation of Kaposi sarcoma.
- Accurate histopathological classification is crucial for diagnosis and management.
Purpose of the Study:
- To evaluate and delineate the histomorphological spectrum of oral Kaposi sarcoma.
- To categorize oral Kaposi sarcoma based on predominant growth patterns.
Main Methods:
- Retrospective analysis of 135 oral Kaposi sarcoma cases diagnosed between 1990 and 2011.
- Histologic review and classification into seven distinct patterns: solid, lymphangioma-like, telangiectatic, desmoplastic, lymphangiectatic, ecchymotic, and anaplastic.
- Identification of coexistent pathologies.
Main Results:
- Seven distinct histomorphological patterns of oral Kaposi sarcoma were identified.
- Coexistent pathologies, primarily candidiasis, were observed in 25 cases.
- Cytomegalovirus and non-necrotizing granulomatous inflammation were also noted.
Conclusions:
- Recognizing the diverse histomorphological patterns of oral Kaposi sarcoma is essential for accurate diagnosis.
- Distinguishing these patterns from other oral lesions is critical.
- Further research is needed to determine the prognostic significance of these variants.
