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Related Experiment Video

Updated: May 15, 2026

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

Published on: January 7, 2019

Incidental hyperdensities within the reticuloendothelial system.

Smbat Amirbekian¹, Saad M Ibrahim, Myung Soo Shin

¹Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520-8042, USA. smbat.amirbekian@yale.edu.

Clinical Imaging

|January 15, 2013

Summary

This summary is machine-generated.

This case report highlights a rare instance of thorium dioxide (Thorotrast) exposure, identified by distinctive hyperdense lesions in the liver, lymph nodes, and spleen. Early detection is crucial due to the increased risk of malignancy.

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Area of Science:

Radiology
Toxicology
Oncology

Background:

Thorium dioxide (Thorotrast) was historically used as a contrast agent.
Its long-term sequelae, including malignancy, are a significant public health concern.
Incidental findings on imaging necessitate awareness of rare toxic exposures.

Observation:

A 79-year-old woman presented with incidentally discovered hyperdense nodular lesions in the upper abdomen.
Imaging revealed a reticular pattern in the liver, dense lymph nodes, and a shrunken spleen.
These findings suggested a specific etiology related to prior contrast agent administration.

Findings:

The constellation of imaging findings strongly indicated chronic thorium dioxide deposition.
Differential diagnoses were considered and systematically excluded.
The characteristic imaging pattern is key to identifying this rare exposure.

Implications:

Physicians must recognize the characteristic imaging findings of thorium dioxide exposure.
Prompt diagnosis is critical for initiating surveillance for associated malignancies.
Understanding the pathophysiology aids in managing long-term complications.