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Related Experiment Video

Updated: May 15, 2026

Transmesenteric Laparoscopic Pyeloplasty in Trendelenburg Position for Horseshoe Kidney with Hydronephrosis
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Changes in differential renal function after pyeloplasty in children.

Ahmed M Harraz1, Tamer Helmy, Diaa-Eldin Taha

  • 1Urology and Radiology (IS) Departments, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

The Journal of Urology
|January 15, 2013
PubMed
Summary

Pediatric pyeloplasty improves differential renal function. Preoperative differential renal function and cortical thickness predict post-surgery improvement in kidney function.

Keywords:
APDRFRFT[1/2]USanteroposteriorbaseline weightedbwdifferential RFeGFRestimated glomerular filtration ratehalf-timekidneykidney function testsoutcome assessment (health care)renal functionultrasoundureterureteral obstruction

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Area of Science:

  • Pediatric Urology
  • Nephrology
  • Surgical Outcomes

Background:

  • Controversial outcomes of differential renal function after pediatric pyeloplasty.
  • Previous studies limited by power, methodology, and endpoints.
  • Need for robust data on renal function post-pyeloplasty in children.

Purpose of the Study:

  • To determine differential renal function status after pyeloplasty in children.
  • To identify predictors of renal function improvement post-pyeloplasty.
  • To present findings from the largest series to date.

Main Methods:

  • Retrospective analysis of 196 children under 18 undergoing pyeloplasty.
  • Exclusion of patients with renal anomalies, solitary kidney, or bilateral pyeloplasty.
  • Preoperative and postoperative renal scintigraphy used to assess differential renal function.

Main Results:

  • Mean differential renal function improved from 35.8% to 38.7% (p <0.001).
  • Improvement observed in poor and intermediate function groups; static in the good function group.
  • Baseline differential renal function (<35% or 35%-40%) and cortical thickness predicted >5% improvement.

Conclusions:

  • Pyeloplasty leads to improved renal function in pediatric patients.
  • Baseline differential renal function and cortical thickness are key predictors of surgical success.
  • This study provides significant insights into predicting pyeloplasty outcomes.