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Current evidence on the relationship between five polymorphisms in the matrix metalloproteinases (MMP) gene and lung

Chaoliang Hu1, Jianmiao Wang, Yuzhu Xu

  • 1Department of Respiratory Diseases, Tongji Hospital, Key Lab of Pulmonary Diseases of Health Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Gene
|January 15, 2013
PubMed
Abstract

Insights

This meta-analysis found that certain matrix metalloproteinase (MMP) gene polymorphisms are associated with lung cancer risk. Specifically, MMP1-1607 1G/2G increased risk in Asians, while MMP2-1306 C/T and MMP9-1562 C/T showed protective effects in specific ethnic groups.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Matrix metalloproteinases (MMPs) are crucial in cancer progression.
  • Polymorphisms in MMP genes (MMP1, MMP2, MMP3, MMP9) have been investigated for their role in lung cancer susceptibility.
  • Previous studies yielded conflicting results, necessitating a comprehensive meta-analysis.

Purpose of the Study:

  • To clarify the association between specific MMP gene polymorphisms and lung cancer risk.
  • To analyze polymorphisms including MMP1-1607 1G/2G, MMP2-735 C/T, MMP2-1306 C/T, MMP3-1171 5A/6A, and MMP9-1562 C/T.
  • To conduct subgroup analyses based on ethnicity.

Main Methods:

  • A systematic literature search was performed across multiple databases (Medline, EMBASE, OVID, CBMD) from January 2000 to August 2012.
  • Meta-analysis included 17 studies examining five polymorphic sites in four MMP genes.
  • Odds ratios (OR) with 95% confidence intervals (95%CI) were calculated to assess the strength of associations.

Main Results:

  • MMP1-1607 1G/2G polymorphism was associated with increased lung cancer risk (OR=1.14) under a dominant model, particularly in Asian populations.
  • MMP2-1306 C/T polymorphism showed a decreased lung cancer risk (dominant OR=0.63, recessive OR=0.61).
  • MMP9-1562 C/T polymorphism (TT genotype) was linked to reduced lung cancer risk (OR=0.38) in Caucasians under a recessive model.

Conclusions:

  • MMP1-1607 1G/2G polymorphism is a risk factor for lung cancer in Asians.
  • MMP2-1306 C/T and MMP9-1562 C/T polymorphisms may confer protection against lung cancer in specific ethnic groups.
  • No significant association was found for MMP2-735 C/T and MMP3-1171 5A/6A polymorphisms with lung cancer risk.

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