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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Airway, feeding and growth in infants with Robin sequence and sleep apnoea

M Daniel1, S Bailey, K Walker

  • 1Children's Hospital, Westmead, Sydney, Australia. matija.daniel@nottingham.ac.uk

International Journal of Pediatric Otorhinolaryngology
|January 15, 2013
PubMed

Insights

Infants with Robin sequence often have obstructive sleep apnoea (OSA) and feeding issues. However, OSA severity and interventions did not impact weight at 12 months, suggesting effective management strategies.

Area of Science:

  • Pediatric Surgery
  • Neonatology
  • Craniofacial Anomalies

Background:

  • Robin sequence (RS) is linked to airway abnormalities causing obstructive sleep apnoea (OSA), feeding difficulties, and poor growth.
  • Infants with RS frequently experience functional challenges impacting their development.

Purpose of the Study:

  • To investigate the relationship between OSA severity, interventions for airway and feeding issues, and infant weight at 12 months in Robin sequence patients.
  • To assess the effectiveness of current management strategies for infants with RS and OSA.

Main Methods:

  • Retrospective review of medical records for children with RS managed at a neonatal unit between 1998 and 2010.
  • Analysis of data on OSA severity, airway interventions (including CPAP and mandibular distraction osteogenesis), feeding interventions (tube feeding), and weight centiles at birth, discharge, and 12 months.

Main Results:

  • Severe OSA was diagnosed in 74.4% of the 39 infants studied, requiring more frequent airway interventions and tube feeding compared to mild/moderate OSA.
  • Infants with severe OSA had higher rates of inpatient airway interventions (82.8%) and discharge CPAP (55.2%) than those with mild/moderate OSA (30.0% and 20.0%, respectively).
  • Despite OSA severity and interventions, weight centiles at 12 months showed a similar decline from birth across all groups, indicating no significant influence of OSA severity or interventions on long-term growth.

Conclusions:

  • Obstructive sleep apnoea and feeding difficulties are common in infants with Robin sequence.
  • Weight at 12 months was not significantly influenced by OSA severity, airway interventions, or feeding support.
  • Current management strategies appear effective in promoting comparable growth outcomes for infants with RS, regardless of OSA severity or intervention needs.
Abstract

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