Related Experiment Video
Updated: May 15, 2026

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase
Published on: June 24, 2025
Aβ(1-42) disrupts the expression and function of KLF2 in Alzheimer's disease mediated by p53
Chunyan Wu1, Fengling Li, Guosheng Han
1Department of Neurology, Affiliated Hospital of Weifang Medical University, No. 465 Yuhe Road Kuiwen, Weifang, Shandong 261031, China.
Abstract:
Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Blood brain barrier (BBB) dysfunction and impaired permeability are implicated in the pathological process of AD, but the underlying mechanisms are poorly understood. Kruppel-like factor 2 (KLF2) plays a critical role in regulating vascular functions, including vascular barrier permeability. The expression patterns and functions of KLF2 in AD progress are still unknown. In the current study, we investigated whether alterations in KLF2 contribute to cerebrovascular dysfunction in AD. Our results demonstrated that decreased expression level of KLF2 in the brains of Tg2576 transgenic mice was due to accumulation of Aβ. Importantly, overexpression of KLF2 could completely rescue impaired expression of tight junction protein Occludin induced by Aβ(1-42) in primary human brain endothelial cells (HBMECs). At last, p53 was verified to mediate Aβ(1-42) induced reduction of KLF2. Overall, this is the first time to report that KLF2 is involved in cerebrovascular dysfunction in Alzheimer's disease.
Related Concept Videos
Alzheimer Disease ll: Pathophysiology
Alzheimer Disease l: Introduction
Abnormal Proliferation
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Parkinson Disease ll: Pathophysiology
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

