Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cirrhosis II: Pathophysiology

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

Cirrhosis I: Introduction

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

Chronic Inflammation: Introduction

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Chronic Pancreatitis II: Pathophysiology

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma.

Nature cancer·2026

Same author

Comparing human pediatric immune responses to primary infection with dengue, chikungunya and Zika viruses.

Frontiers in immunology·2025

Same author

Under the Influence: The Epidemic of Excessive Alcohol Use and Its Impact on Heart and Liver Health.

Cardiology in review·2025

Same author

Mixture analysis of associations between environmental and workplace toxins and liver damage and telomere length, stratified by race/ethnicity.

Journal of environmental sciences (China)·2025

Same author

Single-cell RNA sequencing data identify a conserved population of metallothionein-expressing macrophages that may be ubiquitous in vital human organs.

Clinical and translational discovery·2025

Same author

Larsucosterol for the Treatment of Alcohol-Associated Hepatitis.

NEJM evidence·2025

Search research articles

Related Experiment Video

Updated: May 15, 2026

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Published on: March 24, 2015

Dendritic cells and liver fibrosis.

Adeeb H Rahman¹, Costica Aloman

¹Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA.

Biochimica Et Biophysica Acta

|January 15, 2013

Summary

Liver dendritic cells, rare antigen-presenting cells, are crucial for immunity. This review explores their development, characteristics, and role in liver inflammation and fibrosis.

Area of Science:

Immunology
Hepatology
Cell Biology

Background:

Dendritic cells (DCs) are specialized antigen-presenting cells vital for immune system function.
Liver DCs are a heterogeneous population implicated in liver inflammation and fibrosis.
Understanding liver DCs is key to addressing fibrotic liver diseases.

Purpose of the Study:

To review the current knowledge on liver dendritic cells.
To characterize the development and heterogeneity of liver DCs.
To explore the impact of liver DCs on liver fibrosis.

Main Methods:

Literature review of existing research on liver dendritic cells.
Synthesis of data on DC development, characterization, and function in the liver.
Analysis of mechanisms linking liver DCs to fibrosis.

More Related Videos

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Related Experiment Videos

Last Updated: May 15, 2026

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Published on: March 24, 2015

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Main Results:

Liver contains diverse DC subsets with distinct functions.
DCs can promote or resolve liver inflammation depending on context.
Specific DC populations are associated with the progression of liver fibrosis.

Conclusions:

Liver dendritic cells play a significant role in immune responses within the liver.
Their heterogeneity influences their contribution to liver inflammation and fibrosis.
Targeting liver DCs may offer therapeutic strategies for fibrotic liver diseases.