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Updated: May 15, 2026

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Published on: October 17, 2016
Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure
Michalina J Gora1, Jenny S Sauk, Robert W Carruth
1Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Abstract:
Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 μm (lateral) × 7 μm (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.
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