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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacogenetics of Drug Metabolism: Overview01:27

Pharmacogenetics of Drug Metabolism: Overview

Genetic polymorphism in drug metabolism is crucial to the inter-individual variability observed in drug responses. Drug metabolism primarily involves the chemical modification of drugs and other xenobiotics to enhance their elimination by increasing their polarity. Two main classes of enzymes mediate this biotransformation process: Phase I enzymes, primarily cytochrome P450s, catalyze oxidation and reduction reactions, while other enzymes, such as esterases, mediate hydrolysis, and Phase II...

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Related Experiment Video

Updated: May 15, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

Metabolomics perspectives in pediatric research.

Sofia Moco1, Sebastiano Collino, Serge Rezzi

  • 1Nestlé Institute of Health Sciences SA, Proteomics and Metabolomics Core, Lausanne, Switzerland.

Pediatric Research
|January 15, 2013
PubMed
Summary

Prenatal nutrition and lifestyle significantly impact long-term health. Metabolomics offers insights into pediatric diseases, enabling personalized nutrition and preventive medicine strategies.

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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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A Strategy for Sensitive, Large Scale Quantitative Metabolomics
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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)

Published on: March 14, 2013

Area of Science:

  • Systems Biology
  • Nutritional Science
  • Pediatric Research

Background:

  • Prenatal and early nutrition and lifestyle critically influence long-term health and disease predisposition.
  • Metabolomics, a systems biology approach, investigates the genetic-environment-health interplay.
  • Advancements in metabolomics open new research avenues for understanding physiological processes and nutrient functionalities.

Purpose of the Study:

  • To review recent applications of metabolomics in preclinical and clinical fields.
  • To provide insights into disease diagnostics and monitoring.
  • To explore improvements in metabolic regulation for novel therapeutic and nutrition advances in pediatric research.

Main Methods:

  • Review of recent literature on metabolomics applications.
  • Analysis of systems biology approaches and biomarker patterns.
  • Exploration of metabolomic data in relation to pediatric diseases.

Main Results:

  • Metabolomics aids in understanding physiological processes and nutrient functionalities.
  • Systems biology approaches can associate metabolic regulations with multifactorial pediatric diseases.
  • Biomarker patterns offer potential for developing personalized nutrition concepts.

Conclusions:

  • Metabolomics is a valuable tool for preventive medicine and personalized nutrition management.
  • Recent metabolomic applications offer insights into disease diagnostics and metabolic regulation.
  • This approach holds promise for novel therapeutic and nutrition advances in pediatric research.