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Fatty acid control of growth of human cervical and endometrial cancer cells
R P Gleeson1, M Ayub, J T Wright
1Institute of Obstetrics and Gynaecology, Hammersmith Hospital, London, UK.
British Journal of Cancer
|April 1, 1990
Abstract:
Stearic acid and iodo-stearic and inhibited cell growth in a cervical cancer cell line (HOG-1) in a dose-related manner, with a half maximal effect at 50 microM stearic acid. Addition of oleic acid abrogated the effect of stearic acid. EGF-stimulated DNA synthesis and growth of HOG-1 cells was inhibited in the presence of stearic acid without any apparent effect on EGF receptor number or affinity.