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Updated: May 15, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Residual thrombosis after a first episode of proximal deep venous thrombosis

Ana Montes-Worboys1, Elena Arellano, Teresa Elías

  • 1Institute of Biomedicine, University Hospital Virgen del Rocío, CIBERES, Seville, Spain.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|January 15, 2013
PubMed

Insights

Deep venous thrombosis (DVT) ultrasound normalization is infrequent (26.4%) after anticoagulation. Genetic factors and biomarkers like D-dimer and TNF-α influence thrombus resolution.

Area of Science:

  • Vascular Medicine
  • Hematology
  • Medical Diagnostics

Background:

  • Deep venous thrombosis (DVT) is a significant vascular condition.
  • Assessing DVT resolution is crucial for patient management.
  • Compression ultrasonography (C-US) is a primary diagnostic tool.

Purpose of the Study:

  • To analyze the normalization rate of C-US following a first proximal DVT episode.
  • To identify factors influencing the resolution of residual thrombi.

Main Methods:

  • Prospective study involving patients with a first proximal DVT.
  • Serial C-US examinations performed within 3-6 months post-DVT.
  • Analysis of genetic variations (Factor XIII Val34Leu) and biomarker levels (D-dimer, IL-8, TNF-α).

Main Results:

  • The C-US normalization rate was 26.4% within the follow-up period.
  • Factor XIII Val34Leu polymorphism significantly impacted popliteal thrombi improvement (P=0.019).
  • Negative correlation between 3-month D-dimer levels and popliteal thrombi improvement (P=0.016).
  • Positive correlation between baseline femoral thrombi diameter and IL-8 (P=0.015).
  • Significant difference in residual thrombi improvement based on 1-month TNF-α levels (P=0.047).

Conclusions:

  • Ultrasound normalization after standard anticoagulation for DVT is uncommon.
  • Procoagulant and inflammatory biomarkers, along with genetic variations, may play a role in thrombosis resolution.

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