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Serum surfactant protein D is associated with the prognosis in patients with chronic kidney disease

Fangyi Xie1, Xin Wang, Zhen Ding

  • 1Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, PR China.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|January 15, 2013
PubMed

Insights

Serum surfactant protein D (SP-D) levels are linked to poorer 1-year outcomes in Chinese patients with chronic kidney disease (CKD). Higher SP-D indicates an increased risk of major adverse cardiac events (MACEs) in this population.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • Circulating surfactant protein D (SP-D) is associated with cardiovascular disease and mortality in European patients.
  • The prognostic value of SP-D in Chinese patients with chronic kidney disease (CKD) remains unclear.

Purpose of the Study:

  • To investigate the association between serum SP-D levels and the 1-year prognosis of Chinese patients with CKD.
  • To determine if SP-D can serve as a predictive biomarker for major adverse cardiac events (MACEs) in this cohort.

Main Methods:

  • Serum SP-D levels were measured in 264 patients undergoing coronary angiography using ELISA.
  • Chronic kidney disease (CKD) was defined by estimated glomerular filtration rate (eGFR).
  • Patients were followed for 1-year MACEs, with correlations analyzed between SP-D, Gensini scores, hs-CRP, and eGFR.

Main Results:

  • CKD patients exhibited higher SP-D levels compared to non-CKD patients.
  • Serum SP-D levels positively correlated with coronary lesion severity (Gensini scores) and eGFR.
  • Higher SP-D levels (≥200 ng/ml) and CKD were independently associated with an increased risk of 1-year MACEs.

Conclusions:

  • Serum SP-D levels are significantly associated with the 1-year prognosis in Chinese patients with CKD.
  • SP-D may serve as a valuable prognostic biomarker for adverse cardiac events in CKD patients.
Abstract

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