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Updated: May 15, 2026

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
Smoking and marijuana use in pregnancy
Haywood L Brown1, Cornelia R Graves
1Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina, USA. Haywood.brown@duke.edu
Prenatal smoking, including marijuana, poses risks to infant health, potentially causing low birth weight and developmental issues. Pregnant women should receive counseling on the dangers of both cigarette and marijuana use during pregnancy.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Health
- Child Development
Background:
- Prenatal exposure to cigarette smoke is linked to adverse obstetrical, neonatal, and childhood outcomes.
- Cigarette smoking is associated with up to 25% of low birth weight infants and 10% of infant mortality.
- The effects of prenatal marijuana smoking on pregnancy and infant outcomes are less understood, despite marijuana being the most commonly used illicit drug during pregnancy.
Purpose of the Study:
- To review the known risks of prenatal smoking, including both tobacco and marijuana.
- To highlight the association between prenatal smoking and adverse infant outcomes such as preterm birth, fetal growth restriction, and developmental disorders.
- To emphasize the need for counseling pregnant women on the risks of both cigarette and marijuana smoking.
Main Methods:
- Literature review and synthesis of existing research on prenatal smoking and its effects.
- Analysis of data linking prenatal smoking to infant mortality and low birth weight.
- Examination of evidence regarding developmental and hyperactivity disorders in children exposed to smoke in utero.
Main Results:
- Prenatal cigarette smoking is a significant contributor to low birth weight, preterm birth, fetal growth restriction, and infant mortality.
- While not teratogenic, both cigarette and marijuana smoke exposure in pregnancy have been linked to developmental and hyperactivity disorders in children.
- The specific risks of prenatal marijuana smoking require further clarification but are a growing concern.
Conclusions:
- Pregnant women should be advised about the established risks of prenatal cigarette smoking and the emerging concerns regarding marijuana use.
- Counseling on smoking cessation, encompassing both tobacco and marijuana, is crucial for improving obstetrical and neonatal outcomes.
- Further research is needed to fully elucidate the impact of prenatal marijuana exposure on child development.
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