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Related Concept Videos

Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
Exocrine Glands: Unicellular and Multicellular Glands01:29

Exocrine Glands: Unicellular and Multicellular Glands

Exocrine glands are classified as unicellular and multicellular. The unicellular glands are scattered single cells, such as goblet cells, found in the mucous membranes of the small and large intestines. On the other hand, multicellular exocrine glands develop as secretory sheets, like the internal lining of the abdomen or chest. Such secretory sheets release their secretions directly into the lumen of these organs. In addition, some multicellular glands have deep-seated secretory units to...
The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Exocrine Glands: Types of Secretions01:13

Exocrine Glands: Types of Secretions

Exocrine glands produce and release a variety of glandular products. Exocrine glands can be classified into serous, mucous, or mixed types based on their secretory products.
Serous glands produce watery secretions rich in digestive enzymes and proteins. The constituent cells of the serous gland have centrally located nuclei and eosinophilic secretory granules in the cytoplasm. The parotid gland is an example of a serous gland. It secretes saliva, which contains enzymes, such as lipases and...

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Related Experiment Video

Updated: May 15, 2026

Extraction, Labeling, and Purification of Lineage-Specific Cells from Human Antral Follicles
06:36

Extraction, Labeling, and Purification of Lineage-Specific Cells from Human Antral Follicles

Published on: November 30, 2022

Atypical glandular cells.

John O Schorge1, Jose Alejandro Rauh-Hain

  • 1Division of Gynecologic Oncology, Massachusetts General Hospital, Boston, MA, USA. jschorge@partners.org

Clinical Obstetrics and Gynecology
|January 15, 2013
PubMed
Summary

Atypical glandular cells on a Pap smear are rare, prompting a need for clear management strategies. This review outlines the current approach to evaluating and managing this uncommon but concerning finding.

Area of Science:

  • Gynecology
  • Cytopathology

Background:

  • Atypical glandular cells (AGCs) are found in less than 1% of Pap smears.
  • The rarity of AGCs leads to provider unfamiliarity with appropriate workup and management.
  • A comprehensive evaluation is crucial to rule out various potential diagnoses.

Purpose of the Study:

  • To present the most current strategy for managing rare but suspicious Pap test results indicating atypical glandular cells.
  • To guide healthcare providers in the evaluation of AGCs.

Main Methods:

  • Review of current literature and clinical guidelines for AGC management.
  • Discussion of diagnostic procedures including colposcopy, human papillomavirus (HPV) DNA testing, endocervical curettage, and endometrial sampling.

Main Results:

More Related Videos

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea
11:52

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea

Published on: September 14, 2012

Related Experiment Videos

Last Updated: May 15, 2026

Extraction, Labeling, and Purification of Lineage-Specific Cells from Human Antral Follicles
06:36

Extraction, Labeling, and Purification of Lineage-Specific Cells from Human Antral Follicles

Published on: November 30, 2022

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea
11:52

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea

Published on: September 14, 2012

  • Initial evaluations like colposcopy and HPV testing may not always identify the specific cause of AGCs.
  • A spectrum of possible diagnoses must be considered and excluded.

Conclusions:

  • Management of atypical glandular cells requires a systematic and comprehensive approach.
  • Further investigation is often necessary even after initial diagnostic procedures.