Clinical feasibility of pulmonary perfusion analysis using dynamic computed tomography and a gamma residue function

To create and determine the clinical feasibility of a model based on dynamic computed tomography (CT) and a bolus injection of iodine contrast medium for evaluation of pulmonary perfusion for healthy individuals and for patients with lung diseases.

We analyzed pulmonary perfusion by means of dynamic 16-row multidetector CT scanning with a gamma residue function with adding a linear component (extended gamma function model) for 20 healthy individuals and in five patients.

Four types of the time-attenuation curve (TAC) were identified for the peripheral lung. Although the TACs of most pixels for the peripheral lung comprised a single peak or a single-peak followed by another increase, no peak was observed for a small proportion of pixels, which either increased linearly or resulted in a delayed peak for healthy subjects. The ratios of these linearly increasing or delayed peak types of lung fields increased for pathological lungs. The analytical results for pathological cases showed that changes in lung perfusion, difficult to identify using only CT imaging, could be detected.

The extended gamma function model adequately evaluated pulmonary perfusion not only for normal regions, but also for structurally abnormal regions. Regional changes in perfusion could be evaluated by use of our model, and we confirmed its clinical feasibility for pulmonary perfusion analysis.