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Pseudohypoparathyroidism with diabetes mellitus and hypothyroidism

Bedangshu Saikia1, Sunaina Arora, Jacob M Puliyel

  • 1Department of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi, India. bedangshu@gmail.com

Indian Pediatrics
|January 15, 2013
PubMed

Insights

This study details a child with pseudohypoparathyroidism (PHP) who developed type 1 diabetes mellitus (T1DM). This is the first reported association between PHP and T1DM, highlighting a potential new link in G protein pathway disorders.

Area of Science:

  • Endocrinology
  • Genetics
  • Metabolic Disorders

Background:

  • Pseudohypoparathyroidism (PHP) is a genetic disorder affecting G protein signaling.
  • PHP is characterized by resistance to parathyroid hormone (PTH), leading to hypocalcemia.
  • Maternal history of pseudopseudohypoparathyroidism suggests a familial genetic component.

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