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Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis
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Strokes: mimics and chameleons.

Peter M Fernandes1, William N Whiteley, Simon R Hart

  • 1Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK. peterfernandes@nhs.net

Practical Neurology
|January 15, 2013
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Summary
This summary is machine-generated.

Diagnosing stroke can be challenging, as stroke mimics like Todd's paresis or hemiplegic migraine are common. Misdiagnosis may lead to inappropriate treatments, highlighting the need for accurate stroke diagnosis.

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Area of Science:

  • Neurology
  • Emergency Medicine

Background:

  • Accurate stroke diagnosis is critical for timely and effective treatment.
  • Stroke mimics, conditions presenting with stroke-like symptoms, complicate diagnosis.

Observation:

  • Stroke mimics, including Todd's paresis and hemiplegic migraine, account for 20-25% of suspected stroke cases.
  • These mimics can present with non-apoplectic onset or symptoms not fitting a clear arterial territory.

Findings:

  • The presentation of stroke mimics can be mistaken for actual stroke.
  • The tempo of symptom onset and symptom localization are key diagnostic challenges.

Implications:

  • Patients with stroke mimics may not benefit from standard stroke therapies like thrombolysis.
  • Misdiagnosis can lead to harm from inappropriate treatments and delayed care for the actual underlying condition.