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Updated: May 15, 2026

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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Specific Conformational States of Ras GTPase upon Effector Binding

Julie Baussand1, Jens Kleinjung

  • 1Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

Journal of Chemical Theory and Computation
|January 15, 2013
PubMed
Summary

Ras GTPase binding to effectors involves subtle, local conformational changes. A computational method identified specific signaling routes and hot-spot residues, revealing mechanisms for effector specificity and Ras stabilization.

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