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Receptor oligomerization: from early evidence to current understanding in class B GPCRs
Stephanie Y L Ng1, Leo T O Lee, Billy K C Chow
1Endocrinology, School of Biological Sciences, The University of Hong Kong Hong Kong, China.
Abstract:
Dimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction, and internalization. Class B GPCRs are receptors to a family of hormones including secretin, growth hormone-releasing hormone, vasoactive intestinal polypeptide and parathyroid hormone, among others. The functional implications of receptor dimerization have extensively been studied in class A GPCRs, while less is known regarding its function in class B GPCRs. This article reviews receptor oligomerization in terms of the early evidence and current understanding particularly of class B GPCRs.
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