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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...

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Related Experiment Video

Updated: May 15, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Long Non-Coding RNAs in Infection Biology.

Vinod Scaria1, Ayesha Pasha

  • 1GN Ramachandran Knowledge Center for Genome Informatics, Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research Delhi, India.

Frontiers in Genetics
|January 15, 2013
PubMed
Summary

Long non-coding RNAs (lncRNAs) are key regulators in cellular mechanisms. Emerging research reveals their critical roles in host-pathogen interactions and immune responses during infection.

Keywords:
host-pathogen interactionsimmuneinfectionlong non-coding RNApathogen

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

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Last Updated: May 15, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

Area of Science:

  • Molecular Biology
  • Genetics
  • Immunology

Background:

  • Long non-coding RNAs (lncRNAs) are a significant class of non-coding RNAs with crucial roles in cellular mechanisms.
  • Human lncRNA annotations indicate a number comparable to protein-coding genes, yet most functions remain uncharacterized.
  • lncRNAs are implicated in cancer, X-inactivation, and epigenetic regulation.

Purpose of the Study:

  • To review and synthesize current findings on the role of lncRNAs in infection biology.
  • To highlight the involvement of lncRNAs in host-pathogen interactions and immune responses.
  • To identify challenges and future research directions in understanding lncRNA functions in infection.

Main Methods:

  • Literature review and commentary on existing research.
  • Analysis of studies investigating lncRNA involvement in host-pathogen crosstalk.
  • Synthesis of data on lncRNA-mediated immune functions.

Main Results:

  • Recent reports suggest lncRNAs play a role in host response and immune function during infection.
  • The current understanding of lncRNAs in host-pathogen interactions is based on a limited number of examples.
  • lncRNAs may mediate complex regulatory networks involved in infection.

Conclusions:

  • lncRNAs represent a promising area for understanding infection biology and immune regulation.
  • Further research is needed to elucidate the functional significance and mechanisms of lncRNAs in host-pathogen interactions.
  • Addressing current bottlenecks is crucial for advancing the field of lncRNA in infection research.