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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

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In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...

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Related Experiment Video

Updated: May 15, 2026

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

Published on: January 19, 2010

Haemorrhagic colitis caused by dasatinib.

Nishant Patodi1, Nidhi Sagar, Zbigniew Rudzki

  • 1Department of Gastroenterology, Heart of England Foundation Trust, Birmingham B9 5SS, UK.

Case Reports in Hematology
|January 15, 2013
PubMed
Summary

Dasatinib therapy can cause gastrointestinal bleeding. This case highlights a rare complication, haemorrhagic colitis, in a chronic myeloid leukaemia patient, which resolved upon stopping dasatinib treatment.

Related Experiment Videos

Last Updated: May 15, 2026

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

Published on: January 19, 2010

Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacology

Background:

  • Dasatinib is a tyrosine kinase inhibitor used to treat chronic myeloid leukaemia (CML).
  • Gastrointestinal bleeding is a known, albeit infrequent, adverse effect of dasatinib therapy.
  • Haemorrhagic colitis is an extremely rare complication associated with dasatinib.

Purpose of the Study:

  • To report a rare case of haemorrhagic colitis in a patient with CML treated with dasatinib.
  • To emphasize the importance of considering rare adverse events in clinical practice.
  • To highlight the reversibility of this complication upon drug withdrawal.

Main Methods:

  • Case report presentation.
  • Review of patient's medical history and treatment course.
  • Clinical observation of symptoms and response to intervention.

Main Results:

  • A 59-year-old male with CML developed severe gastrointestinal bleeding.
  • The patient was diagnosed with haemorrhagic colitis, a rare dasatinib-induced complication.
  • Symptoms rapidly improved and resolved after discontinuation of dasatinib therapy.

Conclusions:

  • Haemorrhagic colitis is a rare but serious adverse event that can occur during dasatinib therapy for CML.
  • Prompt recognition and withdrawal of dasatinib are crucial for managing this complication.
  • This case underscores the need for vigilance regarding uncommon side effects of targeted cancer therapies.