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Cytogenetics of carcinoma in situ of the testis
A Vos1, J W Oosterhuis, B de Jong
1Department of Medical Genetics, State University of Groningen, The Netherlands.
Cancer Genetics and Cytogenetics
|May 1, 1990
Abstract:
Carcinoma in situ (CIS) of the testis is the precursor lesion of most testicular germ cell tumors (TGCTs). Karyotyping of CIS is important for a better understanding of the pathogenesis of TGCTs and the progression to invasive cancer. We karyotyped three cases of CIS. All three cases showed a numerical abnormal chromosomal pattern. In one case, two copies of the germ cell tumor marker i(12p) were found.