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Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...

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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Lipid Absorption

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Related Experiment Video

Updated: May 15, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

Colesevelam: a new and improved bile acid sequestrant?

Konstantinos Tziomalos¹, Asterios Karagiannis, Dimitri P Mikhailidis

¹First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece. ktziomalos@yahoo.com

Current Pharmaceutical Design

|January 16, 2013

Summary

Colesevelam, a bile acid sequestrant, effectively lowers low-density lipoprotein cholesterol (LDL-C) in patients unable to reach targets with statins. It also improves glycemic control and is generally well-tolerated.

Related Experiment Videos

Last Updated: May 15, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

Area of Science:

Cardiology and Endocrinology
Pharmacology

Background:

Statins are crucial for cardiovascular prevention but many patients do not achieve low-density lipoprotein cholesterol (LDL-C) targets.
Patient statin intolerance or inability to reach therapeutic LDL-C levels necessitates alternative treatments.

Purpose of the Study:

To evaluate colesevelam as a treatment option for patients with hyperlipidemia who are statin-intolerant or have not reached LDL-C goals.

Main Methods:

Review of studies on colesevelam's efficacy and safety in managing LDL-C levels.
Assessment of colesevelam's impact on glycemic control and patient tolerability.

Main Results:

Colesevelam effectively reduces serum LDL-C levels.
The drug demonstrates potential benefits in improving glycemic control.
Short-term studies indicate favorable tolerability.

Conclusions:

Colesevelam is a valuable therapeutic option for high-risk cardiovascular patients who cannot achieve LDL-C targets with statin monotherapy.
Its dual action on LDL-C and glycemic control makes it a promising agent in lipid management.