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Assay Development for High-Throughput Drug Screening Against Mycobacteria
Published on: October 25, 2024
Revisiting eukaryotic anti-infective biotherapeutics
Praveen Rishi1, Aman Preet Singh, Sumeha Arora
1Department of Microbiology, Panjab University , Chandigarh, Chandigarh , India and.
Critical Reviews in Microbiology
|January 16, 2013
Summary
Novel antimicrobial strategies from herbal products and antimicrobial peptides are explored as alternatives to combat emerging drug resistance. These eukaryotic agents offer versatile applications, alone or with antibiotics, with limitations also discussed.
Area of Science:
- Microbiology and Pharmacology
- Natural Product Chemistry
- Drug Discovery
Background:
- Increasing antimicrobial resistance necessitates the exploration of alternative therapeutic agents.
- Traditional knowledge and folklore offer potential sources for novel drug candidates.
- Eukaryotic-derived compounds, including herbal products and antimicrobial peptides, are gaining prominence.
Purpose of the Study:
- To review the therapeutic potential of eukaryotic-derived agents against infectious diseases.
- To evaluate the use of herbal products and antimicrobial peptides as standalone or combination therapies.
- To discuss the limitations and concerns associated with these alternative antimicrobial strategies.
Main Methods:
- Comprehensive literature review of observational data and scientific studies.
- Analysis of native and designer forms of herbal products and antimicrobial peptides.
- Evaluation of combination therapies with conventional antibiotics.
Main Results:
- Herbal products and antimicrobial peptides show promise as effective alternatives to conventional antibiotics.
- These agents exhibit versatile applications in treating various infectious diseases.
- Potential benefits and drawbacks of using these natural compounds are identified.
Conclusions:
- Eukaryotic-derived agents represent a valuable addition to the antimicrobial armamentarium.
- Further research is warranted to optimize their therapeutic use and address safety concerns.
- These alternatives offer a promising avenue for combating drug-resistant infections.
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