Related Experiment Video
Updated: May 15, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
[Continuous medical evaluation of the prevention of fetomaternal rhesus-D allo-immunization]
B Viaris de Lesegno1, G Beucher, N Lamendour
1Service de gynécologie-obstétrique et médecine de la reproduction, CHU de Caen-FEH, avenue de la Côte-de-Nacre, 14033 Caen cedex 9, France. benjamindeviaris@gmail.com
Objectives:
To evaluate the prevention of fetomaternal rhesus-D allo-immunization between 2008 and 2010. This evaluation was a part of the continuous medical evaluation (CME) that is compulsory in French hospitals. It was carried out using the tools recommended by the Haute Autorité de santé. We followed the national guidelines for the prevention of fetomaternal rhesus-D allo-immunization as outlined in 2005 by the national French college of Obstetrics and Gynecology.
Materials And Methods:
We audited 3926 consultations in the first four months of 2008. Based on the results of the audit, actions were implemented to improve care. In 2009, we audited 4021 consultations to look for improvement, and another 3932 consultations in 2010.
Results:
In 2008, 14% of the patients had an overall optimal prevention. After actions were taken, 44% of patients in 2009 and 58% of patients in 2010 demonstrated optimal prevention (P<0,05). Especially, the prevention of fetomaternal allo-immunization has been explained for 43% of the patients in 2008 and to 90% of them in 2010. And immunoprophylaxia has been prescribed to 70% of the patients in 2008 and to 93% of them in 2010.
Conclusion:
This CME has resulted in a statistically significant improvement of the prevention of allo-immunization.
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