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Related Experiment Video

Updated: May 15, 2026

Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model
05:52

Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model

Published on: November 4, 2021

Aneurysm embolization with biologically active coils: an animal study.

Sandeep K Agrawal1

  • 1Division of Neurosurgery, Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA. agrawals@unmc.edu

Neurological Research
|January 16, 2013
PubMed
Summary

Coating Guglielmi detachable coils (GDC) with transforming growth factor beta (TGF-beta) or vascular endothelial growth factor (VEGF) significantly enhanced aneurysm occlusion in rats. These growth factors promote better clot organization and cellular integration for improved aneurysm repair.

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Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Regenerative Medicine

Background:

  • Guglielmi detachable coils (GDC) are used for aneurysm occlusion.
  • Cellular adhesion to GDC surfaces aids aneurysm closure.
  • Optimizing GDC coatings can improve aneurysm treatment outcomes.

Purpose of the Study:

  • To investigate if transforming growth factor beta (TGF-beta) and vascular endothelial growth factor (VEGF) coated coils enhance aneurysm occlusion.
  • To compare the efficacy of TGF-beta and VEGF coated GDC against uncoated GDC in experimental aneurysms.

Main Methods:

  • Guglielmi detachable coils (GDC) were coated with TGF-beta or VEGF.
  • Coated and uncoated GDC were implanted in rat carotid arteries for 14 days.
  • Histopathological analysis of arterial tissue and coil integration was performed.

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Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects
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Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects

Published on: May 11, 2011

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Last Updated: May 15, 2026

Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model
05:52

Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model

Published on: November 4, 2021

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects
07:34

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects

Published on: May 11, 2011

Main Results:

  • Coated GDC (TGF-beta and VEGF groups) showed significantly reduced aneurysm luminal area compared to uncoated GDC.
  • Histopathology revealed well-organized fibrous tissue and intimal hyperplasia around coated GDC.
  • TGF-beta and VEGF coatings promoted better cellular integration and tissue formation.

Conclusions:

  • GDC coated with TGF-beta or VEGF demonstrate improved performance in promoting aneurysm occlusion.
  • These growth factor coatings facilitate endothelization, clot organization, and tissue integration.
  • Coated GDC show potential for enhancing the efficacy of endovascular aneurysm repair.