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Immunosuppressive monoclonal antibody to CD64 from patients with long-term stable multiple sclerosis
P Annunziata1, C Cioni, L Cantalupo
1Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy. annunziata@unisi.it
Abstract:
High intrathecal levels of anti-myelin basic protein (MBP) IgM were previously found to be significantly associated with early favorable course in a cohort of patients with multiple sclerosis (MS). A mAb to MBP 105-120 recognizing the 222-228 epitope of the extracellular domain of high affinity immunoglobulin gamma Fc-receptor I (CD64) was isolated from EBV(+) B cell clones of long-term stable RRMS patients. This mAb exerted immunosuppressive activity on MS-derived T cell lines through induction and release of high amounts of interleukin-10 and decreased levels of interleukin-12 from activated monocytes providing the biological basis for a potential new treatment for MS and other immune-mediated neurological disorders.
