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Updated: May 15, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Adherence between antibiotic prescriptions and guidelines in an internal medicine ward: an evaluation of
C Peix1, M-A Vandenhende, F Bonnet
1Pharmacie, groupe hospitalier Saint-André, 1 rue Jean-Burguet, Bordeaux cedex, France.
Introduction:
This is an evaluation of professional practices (EPP) on antibiotic therapy in an internal medicine ward.
Material And Methods:
A 6-month prospective review of antibiotic prescriptions and their comparisons with local and national guidelines (drug, daily dose, administration, and duration) were performed.
Results:
Antibiotic therapy on 227 infectious episodes was collected. According to local guidelines, we found 56% of totally respected (lower respiratory tract infections: 38%, urinary tract infections: 88% and skin infections: 73%), 33% of partially respected and 11% of non-appropriate prescriptions. Considering national guidelines for lower respiratory tract infections as references, the results were: totally respected prescriptions 81%, partially respected prescriptions 16%, and non-appropriate prescriptions 3%.
Conclusion:
This evaluation of the prescriptions allowed setting up long-lasting actions to improve clinical practice. This approach anticipates the procedures of EPP that will be needed for hospital accreditation and highlights the importance of considering several guidelines for the interpretation of the results.
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