Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 15, 2026

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Published on: July 29, 2013

Four-dimensional tissue deformation reconstruction (4D TDR) validation using a real tissue phantom.

Martin Szegedi¹, Jacob Hinkle, Prema Rassiah

¹Department of Radiation Oncology, University of Utah, Salt Lake City, UT 84112, USA. martin.szegedi@hci.utah.edu

Journal of Applied Clinical Medical Physics

|January 16, 2013

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same authorSame journal

Implementation of VMAT-based lattice spatially fractionated radiation therapy (SFRT) across linac platforms: Practical considerations for QA and motion management.

Journal of applied clinical medical physics·2026

Same author

Intrafraction Motion Mitigation by Rectal Spacers in Prostate Stereotactic Body Radiation Therapy: Balloon, Hydrogel, and No-Spacer Comparison.

Practical radiation oncology·2026

Same author

Deep Learning Driven Evaluation of MR-guided Focused Ultrasound Ablation.

IEEE transactions on bio-medical engineering·2026

Same author

FAK inhibition following acute olfactory epithelial inflammation promotes neurogenesis and functional recovery through stem cell CNTF.

Stem cells (Dayton, Ohio)·2026

Same author

Metabolome contribution to sex differences in the link between alcohol consumption and type 2 diabetes: a prospective analysis in the Hispanic Community Health Study/Study of Latinos.

The American journal of clinical nutrition·2026

Same author

ARD-VAE: A Statistical Formulation to Find the Relevant Latent Dimensions of Variational Autoencoders.

IEEE Winter Conference on Applications of Computer Vision. IEEE Winter Conference on Applications of Computer Vision·2025

A new algorithm, 4D tissue deformation reconstruction (4D TDR), accurately models tissue motion along the entire path, including hysteresis effects. This improves accuracy for four-dimensional (4D) dose calculations in radiation therapy.

Area of Science:

Medical Physics
Radiotherapy
Image Processing

Background:

Four-dimensional (4D) dose calculations require remapping dose data from various 4D CT phases to a reference phase.
Deformable image registration (DIR) is commonly used but often neglects the full motion path, focusing only on endpoints.
This limitation impacts the accuracy of dose distribution calculations in dynamic scenarios.

Purpose of the Study:

To verify the accuracy of a novel algorithm, 4D tissue deformation reconstruction (4D TDR), for reconstructing 4D motion data.
To assess the performance of 4D TDR, including a modified version accounting for tissue hysteresis (4D TDR(Hysteresis)).
To compare the algorithm's accuracy against electromagnetic tracking (EMT) and 4D CT measurements using a realistic tissue phantom.

Main Methods:

More Related Videos

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Published on: February 12, 2018

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Published on: January 11, 2020

Related Experiment Videos

Last Updated: May 15, 2026

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Published on: July 29, 2013

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Published on: February 12, 2018

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Published on: January 11, 2020

A fresh tissue phantom with implanted electromagnetic tracking (EMT) fiducials was used.
The phantom was animated with sinusoidal and real patient-breathing signals.
Four-dimensional CT (4D CT) and EMT tracking were performed concurrently.
Deformation reconstruction was conducted using 4D TDR and 4D TDR(Hysteresis).
Results were compared to EMT and 4D CT data, with fiducials masked to isolate algorithm performance.

Main Results:

For sinusoidal motion, 4D TDR showed an average deviation of 1.9 mm from 4D CT, with 95% of EMT traces within 2.8 mm.
4D TDR(Hysteresis) accurately modeled tissue hysteresis, achieving 95% of EMT traces within 1.6 mm for sinusoidal motion.
Under irregular patient breathing, 4D TDR(Hysteresis) demonstrated average deviations of 0.9-1.0 mm from 4D CT and 95% of EMT traces within 4.5 mm.

Conclusions:

The 4D TDR algorithm accurately reconstructs 4D motion data along the entire path, unlike endpoint-only DIR methods.
Incorporating tissue hysteresis (4D TDR(Hysteresis)) significantly improves the modeling of real-world tissue deformation.
This enhanced accuracy is crucial for reliable four-dimensional dose calculations in radiotherapy, minimizing assumptions and improving treatment planning.