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Related Experiment Video

Updated: May 15, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

New-onset microalbuminuria following allogeneic myeloablative SCT is a sign of near-term decrease in renal function.

T Morito1, M Ando, T Kobayashi

  • 1Department of Medicine, Division of Nephrology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.

Bone Marrow Transplantation
|January 16, 2013
PubMed
Summary
This summary is machine-generated.

Emergence of microalbuminuria after conditioning chemotherapy signals increased risk for kidney dysfunction. Early detection of microalbuminuria in patients undergoing allogeneic stem cell transplant can predict chronic kidney disease.

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Last Updated: May 15, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Area of Science:

  • Nephrology
  • Oncology
  • Hematology

Background:

  • Conditioning chemotherapy prior to hematopoietic stem cell transplantation (HSCT) can cause kidney damage.
  • Microalbuminuria, the presence of albumin in urine, is an early indicator of kidney disease.
  • The predictive value of microalbuminuria for renal dysfunction post-HSCT requires further investigation.

Purpose of the Study:

  • To investigate whether de novo microalbuminuria following conditioning chemotherapy predicts the development of renal dysfunction in patients undergoing myeloablative allogeneic HSCT.
  • To assess the association between microalbuminuria and the incidence of chronic kidney disease (CKD) after HSCT.

Main Methods:

  • A retrospective cohort study of 31 patients undergoing myeloablative allogeneic HSCT.
  • Albuminuria and estimated glomerular filtration rate (eGFR) were measured before conditioning and on days 0, 7, 14, and 28 post-HSCT.
  • Kaplan-Meier analysis and multivariate Cox proportional hazards analysis were used to evaluate the risk of renal dysfunction.

Main Results:

  • 52% of patients developed de novo microalbuminuria (albumin-creatinine ratio > 30 mg/g) at least twice after HSCT.
  • Patients with de novo microalbuminuria had a significantly higher incidence of CKD (eGFR < 60 mL/min/1.73 m²).
  • De novo microalbuminuria was a significant risk factor for subsequent renal dysfunction (Hazard Ratio: 7.3; 95% CI: 1.2-140).

Conclusions:

  • De novo microalbuminuria emerging after conditioning chemotherapy is a critical warning sign for impending renal function loss.
  • Monitoring for microalbuminuria post-HSCT is crucial for early identification of patients at high risk for renal dysfunction.
  • This finding supports proactive renal protective strategies in HSCT recipients who develop microalbuminuria.