Metabolic and endocrine diseases, cartilage calcification and arthritis

Osteoarthritis is the most common form of rheumatologic disease, with numerous factors increasing the risk of developing the condition; calcification of cartilage is common place in osteoarthritis. Regardless of these risk factors, certain disorders predispose individuals to developing arthritis. Pathologic mechanisms in cartilage calcification and advances in their understanding are reviewed alongside metabolic and endocrine arthritis.

There is growing evidence suggesting that changes in chondrocytes and the extracellular environment both contribute to the calcification. Further evidence suggests that signaling cascades that are involved in physiological mineralisation are involved in the pathological process(es); data in mouse models continue to add weight to these hypotheses and correlate with human osteoarthritis data. Recent study of rare forms of arthritis is adding useful information that may help understand joint diseases in the general population and how therapies may be targeted.

There is little doubt that calcium-containing crystals are involved in the osteoarthritis process contributing both biomechanically and biochemically. Understanding the processes involved provides important therapeutic opportunities. Furthermore, important information is often discovered in studying rare conditions in which these pathologies are inevitable.