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Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.

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Related Experiment Video

Updated: May 15, 2026

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

[Lymph node pathology - an update].

S Hartmann1, M L Hansmann

  • 1Senckenbergisches Institut für Pathologie, Klinikum der J. W. Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland. s.hartmann@em.uni-frankfurt.de

Der Pathologe
|January 16, 2013
PubMed
Summary
This summary is machine-generated.

Immune suppression increases lymphoma risk, particularly in transplant recipients and those with autoimmune diseases. The article reviews these lymphomas and challenging "gray zone" lymphomas.

Related Experiment Videos

Last Updated: May 15, 2026

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

Area of Science:

  • Oncology
  • Immunology
  • Pathology

Context:

  • Increasing numbers of immunosuppressed patients due to organ transplantation and autoimmune disease treatment.
  • Immune suppression is a known risk factor for the development of malignant lymphomas.
  • Advances in medical science have led to a rise in patients requiring immunosuppression.

Purpose:

  • To discuss different forms of immune suppression and their associated lymphoma entities.
  • To explore the diagnostic challenges and biological continuum of gray zone lymphomas.
  • To provide an overview of lymphoma development in immunosuppressed individuals.

Summary:

  • This article examines the link between immune suppression and malignant lymphoma development.
  • It details various immunosuppression types and corresponding lymphoma entities.
  • Additionally, it addresses the complexities of gray zone lymphomas, bridging Hodgkin's lymphoma and diffuse large B cell lymphoma.

Impact:

  • Enhances understanding of lymphoma risks in immunosuppressed populations.
  • Highlights diagnostic challenges posed by gray zone lymphomas.
  • Informs clinical management and research directions for these specific lymphoma types.